Unfortunately I have a relatively large Gall Bladder Stone which acts up now and then.It usually takes a lot of Tums and about an hour to subside. Last night I ate a rich dinner and the Gall Bladder pain started. Instead of using Tums and water, I put a good dose of Plus CBDoil under my tongue and then swallowed. I actually felt the CBD go down through my system and hit the Gall Bladder Pain. To my amazement, the pain disappeared within 15 seconds. I still can't believe it!!!!